Seminar on imaging applications in research including clinical aspects with a focus on neuroscience

Type of class Seminar

Offered by Medical Neurosciences

Instructor PD Dr. Andreas Wunder

Schedule 8 Sessions (starting on Mai 10th 2010, Monday 17:30 - 19:45)

Location Humboldt Graduate School, Luisenstr. 56, 10117 Berlin
Room: tba

Contact PD Dr. Andreas Wunder ()

Target audience MSc and PhD students

ECTS points 1 + 1 (seminar presenation)

Course material

• Syllabus (pdf)

Lecturers

Prof. Eyk Schellenberger and PD Dr. Andreas Wunder

Outcome

Modern imaging technologies such as computed tomography (CT), magnetic resonance tomography (MRT), nuclear imaging methods (positron emission tomography = PET; single photon counting computed tomography = SPECT), and optical imaging technologies (fluorescence and bioluminescence imaging) play an important role to evaluate physiological and pathophysiologi-cal processes non-invasively in research and clinical settings. The goal of the seminar is to understand how these technologies work in principle (without details), how they can be applied to answer biological questions in animal disease models, and how these technologies are applied in clinical settings. Furthermore, the participants will be trained to work in autonomous working groups and to present scientific topics.

Structure

The seminar consists of eight sessions:

Session 1–4: Introduction to the seminar and comprehensible overview of the field. The participants will be divided into 3 working groups (CT/MRT group, SPECT/PET group, optical imaging group) according to their main interest. Each working group will elaborate two imaging modality on the basis of 3–4 scientific publications (some of them are listed below) and will present their findings to the other participants in the following sessions (Session 5–6). The content of the last 2 sessions is flexible.

Readings

Mandatory

• Garcia-Alloza M et al. Techniques for brain imaging in vivo. Neuromolecular Med. 2004;6:65–78

• Lythgoe MF et al. Neuroimaging of animal models of brain disease. Br Med Bull 2003;65:235–57

• Jacobs AH et al. Human gene therapy and imaging in neurological diseases. Eur J Nucl Med Mol Imaging. 2005;32 Suppl 2:S358–383.

• Cherry SR. In vivo molecular and genomic imaging: new challenges for imaging physics. Phys Med Biol 2004;49:R13-R48

Further

CT

• Garcia-Alloza M et al. Techniques for brain imaging in vivo. Neuromolecular Med. 2004;6:65–78

• Lythgoe MF et al. Neuroimaging of animal models of brain disease. Br Med Bull 2003;65:235–57

• Jacobs AH et al. Human gene therapy and imaging in neurological diseases. Eur J Nucl Med Mol Imaging. 2005;32 Suppl 2:S358–383.

• Cherry SR. In vivo molecular and genomic imaging: new challenges for imaging physics. Phys Med Biol 2004;49:R13-R48

MRI

• Koretsky AP et al. New developments in magnetic resonance imaging of the brain. NeuroRx 2004;1:155–164

• Pirko I et al. Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals. NeuroRx 2005;2: 250–264

• Artemov D. Molecular magnetic resonance imaging with targeted contrast agents. J Cell Biochem 2003;90:518–524

SPECT

• Warwick JM et al. Imaging of brain function using SPECT. Metab Brain Dis 2004;19:113–123

• Devous MD Sr. Single-photon emission computed tomography in neurotherapeutics. NeuroRx 2005;2:237–249

• Meikle SR et al. Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol 2005;50:R45–61

PET

• Jacobs AH et al. PET-based molecular imaging in neuroscience. Eur J Nucl Med Mol Imaging 2003;30:1051–1065

• Tai YF et al. Applications of positron emission tomography (PET) in neurology. J Neurol Neurosurg Psychiatry 2004;75: 669–676

• Alavi A et al. Implications of PET based molecular imaging on the current and future practice of medicine. Sem Nucl Med 2004;34:56–69

Optical

• Licha K. Optical imaging in drug discovery and diagnostic applications. Adv Drug Deliv Rev 2005;57:1087–1108

• Ntziachristos V et al. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotechnol 2005;3:313–320

• Shah K et al. Molecular optical imaging: applications leading to the development of present day therapeutics. NeuroRx 2005;2: 215–225

Search this site

All Keywords A Development A.1 Brain patterning A.2 Neurogenesis and gliogenesis A.3 Stem cells A.4 Axon and dendrite development A.5 Synaptogenesis and activity-dependent development A.6 Developmental cell death A.7 Development of motor, sensory, and limbic systems A.8 Epigenetic factors (hormones, nutrition, experience) A.9 Transplantation and regeneration B Neural excitability, synapses and glia: cellular mechanisms B.1 Neurotransmitters and signaling molecules B.10 Intrinsic membrane properties B.11 Glia-neuron interactions B.2 Ligand gated ion channels B.3 G-protein linked receptors B.4 Ion channels B.5 Transporters B.6 Neurotransmitter release B.7 Synaptic transmission B.8 Synaptic plasticity B.9 Network interactions C Disorders of the nervous system C.1 Neurodegenerative disorders and movement disorders C.10 Sensory disorders C.11 Gene therapy C.12 Cognitive, emotional, and behavioral state disorders C.13 Addiction and drugs of abuse C.14 Behavioral pharmacology C.2 Aging C.3 Developmental disorders C.4 Epilepsy C.5 Ischemia C.6 Demyelinating disorders C.7 Trauma C.8 Neuro-oncology C.9 Neurotoxicity, inflammation, and neuroprotection D Sensory and motor systems D.1 Chemical senses D.10 Spinal cord injury and plasticity D.11 Rhythm and pattern generating circuits: vertebrates and invertebrates D.12 Motor neurons and muscle D.13 Cerebellum D.14 Basal ganglia D.15 Posture and voluntary movements D.16 Brain–machine interface D.17 Comparative anatomy and evolution D.2 Auditory D.3 Vestibular D.4 Multisensory D.5 Vision D.6 Visuomotor processing D.7 Eye movements D.8 Pain D.9 Tactile/somatosensory E Homeostatic and neuroendocrine systems E.1 Neuroendocrine E.2 Cardiovascular regulation E.3 Respiratory regulation E.4 Thermoregulation E.5 Gastrointestinal and urogenital regulation E.6 Stress and the brain E.7 Regulation of food intake and body weight E.8 Biological rhythms and sleep E.9 Brain blood flow, metabolism, and homeostasis F Cognition and behavior F.1 Human cognition and behavior F.2 Animal cognition and behavior F.3 Motivation and emotion F.4 Neuroethology F.5 Theory of mind G Techniques, history and teaching G.1 Neurotechniques G.2 History and teaching of neuroscience G.3 Methods J Language J.0 Psycholinguistics J.1 Language acquisition J.2 Language processing J.3 Reading J.4 Mental lexicon J.5 Language disorders and pathologies K Psychology K.1 Mental processes and functions K.10 Clinical psychology K.11 Personality and individual differences K.12 Developmental psychology K.13 Social psychology K.2 Mental disorders K.3 Attention and perception K.4 Learning K.5 Memory K.6 Language K.7 Cognitive control K.8 Consciousness K.9 Sleep L Philosophy of Mind L.1 Consciousness L.10 Other minds L.11 Artificial intelligence L.12 (Neuro)Ethics L.13 Philosophy of language L.14 Moral responsibility L.2 Intentionality L.3 Self and self-consciousness L.4 Metaphysics of mind L.5 Free will L.6 Perception L.7 Memory L.8 Emotions L.9 Mental causation M Decision-making M.1 Decision-making

Calendar

<February 2012>

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