Prof. Dr. Gudrun Ahnert-Hilger (Faculty)
Website http://www.charite.de/anatomie/veh/seite/HomeP3.1.html
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Affiliation(s) GRK 1123 “Learning and Memory”, Institute of Anatomy, Charité – Universitätsmedizin Berlin, International Graduate Program Medical Neurosciences
Keywords A.4 Axon and dendrite development, B.5 Transporters, B.7 Synaptic transmission, B.8 Synaptic plasticity, E.8 Biological rhythms and sleep
Research Focus:
Regulation of vesicular transmitter storage by heterotrimeric G-proteins;
Interaction of vesicular proteins and membrane sorting at the presynapse;
C3-mediated rho-dependent and rho-independent effects on glial and neuronal growth and function
Methods:
Subcellular fractionation; biochemical and functional studies with synaptic vesicles; area-specific neuronal primary dissociation cultures; astrocyte primary cultures; transfection of primary cells and cell lines; uptake and release of neurotransmitters; immunofluorescence microscopy; knockout out mice for the G-protein alpha subunits Gao, Gao1 Gao2 and Gaq; permeabilization of cells